Endocrine Abstracts

Fibro-adipogenic progenitors (FAPs), a muscle-resident stem cell population, have recently emerged as important actors of muscle regeneration by interacting with myogenic progenitors (MPs) to promote the formation of new muscle fibers. However, in pathological condition, as muscle dystrophies, this coordinated response is lost and then an accumulation of FAPs is observed. In particular, in a mouse model of Duchenne muscle dystrophy (mdx), the accumulation of a specific subpopu...

Purpose: Treatment with tyrosine kinase inhibitors (TKI) has been associated with alterations in circulating thyroid hormone levels, possibly related to perturbations in peripheral thyroid hormone metabolism. In this study, we evaluated the effect of the multi-kinase inhibitor vandetanib on the expression of the three deiodinase selenoenzymes.Materials and Methods: Cell models that endogenously express either D1 (HepG2 and HEK-293), D2 (HeLa and KMH-2) o...